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However, early initiation of chelation has also been associated with DFO toxicity.
2
Herein, we clarify the effect and mechanism of action of DFO on angiogenesis.
3
The DFO must be selected from the ranks of SAA pilots.
4
None of the patients who attained final height had signs of DFO bone toxicity.
5
UUO-induced expression of inflammatory cytokines and extracellular matrix proteins was abrogated by DFO treatment.
6
Increased renal iron content was observed in UUO mice, which was reduced by DFO treatment.
7
Endothelial cell proliferation increased and oxidative stress and apoptosis decreased in ischemic muscles of DFO-treated mice.
8
The density of capillaries and arterioles in ischemic muscle was higher in DFO-treated mice compared to vehicle-treated mice.
9
Conclusion: These findings indicate that DFO promotes revascularization via the activation of vascular endothelial cell function by an Akt-eNOS-dependent mechanism.
10
These results suggest that iron reduction by DFO prevents renal tubulointerstitial fibrosis by regulating TGF-β-Smad signaling, oxidative stress, and inflammatory responses.
11
In an in vivo study, DFO promoted blood flow recovery in response to the hindlimb ischemia in mice with unilateral hindlimb surgery.
12
Dendrite branch number and length were reduced in 6 μm ELT-treated neurons, resulting in blunted dendritic arbor complexity that was similar to DFO-treated neurons.
13
The department gave Imperial a new permit on Friday to disturb fish habitat at the proposed northern Alberta mining site, DFO spokesman Phil Jenkins said.